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目的比较早发型和晚发型子痫前期患者临床指标差异,并探讨相关参数在围产儿结局预测中的作用。方法选择2014年1月至6月住院分娩的62例重度子痫前期患者,分为早发型组(<34周,n=37)和晚发型组(≥34周,n=25),检测并分析所有受试者生化指标及脐动脉血流指数的变化情况及其与围生儿结局的关系。结果两组患者年龄、孕次、产次比较差异均无统计学意义(P均>0.05)。两组血压、分娩孕周、生化指标、脐动脉血流指数、新生儿出生体重、胎盘重量、Apgar评分方面差异均有统计学意义(P<0.05,P<0.01)。新生儿出生体重与总蛋白(TP)、分娩孕周分别成正相关(r=0.671,P<0.01;r=0.880,P<0.01);与脐动脉收缩末期血流速度/舒张末期血流速度(S/D)、24 h尿蛋白分别成负相关(r=-0.677,P<0.01;r=-0.576,P<0.01)。1 min Apgar评分与TP、分娩孕周分别成正相关(r=0.606,P<0.01;r=0.557,P<0.01);与S/D、24 h尿蛋白分别成负相关(r=-0.696,P<0.01;r=-0.720,P<0.01)。结论早发型和晚发型重度子痫前期患者生化指标及超声血流指数比较有明显统计学差异,且与围产儿结局密切相关。
Objective To compare the clinical features of early-onset and late-onset preeclampsia and to explore the role of related parameters in predicting perinatal outcome. Methods Sixty-two patients with severe preeclampsia who were hospitalized from January 2014 to June 2014 were divided into early-onset group (n = 37 for 34 weeks) and late-onset group (n = 25 for ≥34 weeks) All subjects biochemical indicators and changes in umbilical artery blood flow index and its relationship with perinatal outcome. Results There were no significant differences in age, gestational age and parity between the two groups (all P> 0.05). Blood pressure, gestational age, biochemical parameters, umbilical artery blood flow index, newborn birth weight, placental weight, Apgar score were significantly different between the two groups (P <0.05, P <0.01). Neonatal birth weight was positively correlated with TP and gestational age (r = 0.671, P <0.01; r = 0.880, P <0.01) S / D) and 24 h urine protein (r = -0.677, P <0.01; r = -0.576, P <0.01). Apgar score at 1 min was positively correlated with TP and gestational age respectively (r = 0.606, P <0.01; r = 0.557, P <0.01) P <0.01; r = -0.720, P <0.01). Conclusions The biochemical indexes and ultrasonic blood flow index in patients with early-onset and late-onset severe preeclampsia are significantly different, and are closely related to the outcome of perinatal infants.