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近年来发展了新型抗病毒药,具有良好的选择性,本文着重介绍抗病毒基因组复制的新药。在嘧啶类中,溴乙烯脱氧尿苷、碘脱氧胞苷、氨碘尿苷均属选择性抗病毒药,氟碘阿糖胞苷尤有希望。在嘌呤类中,阿糖腺苷用于疱疹病毒性角膜炎及脑炎均有较佳疗效;新发展的开糖环鸟苷选择性高,局部用于疱疹病毒角膜炎,全身用于皮肤、粘膜、生殖器疱疹病毒感染有效。磷酰甲酸抑制病毒 DNA聚合酶,已试用于疱疹病毒角膜炎及唇与生殖器感染。上述新药的出现使疱疹病毒化疗为之改观。
In recent years, the development of a new type of antiviral drugs, with good selectivity, this article focuses on anti-viral genome replication of new drugs. Among the pyrimidines, vinylidene deoxyuridine, iodine deoxycytidine and amiodarone are all selective antiviral drugs, and fluoroiodocarbocyanine is particularly promising. In purines, vidarabine for herpes virus keratitis and encephalitis are better curative effect; the newly developed high sugar ring cycloguanosin selective for topical herpes virus keratitis, the whole body for the skin, Mucosal, genital herpes virus infection effective. Phosphoryl acid inhibits viral DNA polymerase and has been tested for herpesvirus keratitis and lip and genital infections. The emergence of these new drugs make herpes virus chemotherapy improved.