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在大鼠胶原诱导性关节炎（ＣＩＡ）的诱导阶段，给予风寒湿或风湿热刺激，结果显示：１．风寒湿显著降低雌性鼠炎症积分，延迟起病时间。２．风寒湿，风湿热均可显著提高雌性鼠的胶原抗体水平。３．风寒湿显著降低雄性鼠的类风湿因子水平。风湿热显著降低雌性鼠类风湿因子水平。４．风寒湿显著升高雌性鼠血清Ｅ２及Ｔ３含量。提示：１．环境因素对ＣＩＡ的影响具有性别差异，单纯风寒湿环境刺激ＣＩＡ不能作为类风湿性关节炎风寒湿痹模型。２．风寒湿与风湿热均可促进雌性鼠炎症启动阶段的抗体形成。３．风寒湿促进雌性鼠Ｅ２的分泌可能是关节炎症程度降低的主要原因。
In the induction phase of rat collagen-induced arthritis (CIA), given wind cold dampness or rheumatic fever stimulation, the results showed: 1. Cold and dampness significantly reduce female mouse inflammation score, delay onset time. 2. Cold and dampness, rheumatic fever can significantly increase the female mouse collagen antibody levels. 3. Cold and dampness significantly reduced the level of rheumatoid factor in male rats. Rheumatic fever significantly reduces female rat rheumatoid factor levels. 4. Cold and dampness significantly increased serum E2 and T3 in female rats. Tip: 1. Environmental factors on the impact of CIA gender differences, simple cold and humid environment to stimulate CIA can not be used as rheumatoid arthritis rheumatoid arthralgia model. 2. Cold dampness and rheumatic fever can promote antibody formation during the initiation phase of female rat inflammation. 3. Cold and humid to promote the secretion of E2 in female rats may be the main reason for the reduced degree of joint inflammation.