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目的比较高效液相色谱法与化学发光酶免疫分析法测定丙戊酸血药浓度的结果,为临床合理用药提供依据。方法用两种方法分别测定46例使用丙戊酸的患者用药前的血药浓度,比较两种方法测定值的相关性。结果两种测定方法的线性关系回归方程为Y=0.980 2 X+2.477 7(r=0.979 3),两种方法测定结果差异无显著性(P>0.05)。结论高效液相色谱法与化学发光酶免疫分析法测定丙戊酸血药浓度具有相关性,不需相互校正,均可用于丙戊酸血药浓度的常规监测。
Objective To compare the results of HPLC and chemiluminescence enzyme immunoassay for the determination of plasma concentration of valproic acid and provide the basis for clinical rational drug use. Methods Two methods were used to determine the plasma concentration of 46 patients before valproic acid treatment, comparing the two methods to determine the value of the correlation. Results The regression equation of the linear relationship between the two methods was Y = 0.980 2 X + 2.477 7 (r = 0.979 3). There was no significant difference between the two methods (P> 0.05). Conclusion High performance liquid chromatography with chemiluminescence enzyme immunoassay for the determination of plasma concentration of valproic acid is correlated and can be used for the routine monitoring of plasma concentration of valproic acid without mutual correction.