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药源性血液病约占全部血液病的10%,其中以白细胞减少和粒细胞缺乏症发病率最高。一、再生障碍性贫血:药物引起的再生障碍性贫血(再障)分为两类,一类是可逆性骨髓抑制,一类为特异性反应。可逆性骨髓抑制是指因药物抑制骨髓内线粒体中蛋白质合成,铁螯合酶活性降低,血红蛋白不能合成,导致骨髓内幼红细胞、粒细胞和血小板生成障碍。此类药物包括烷化剂和抗代谢药等。国内报道用马利兰治疗慢性粒细胞性白血病及银屑病,诱发了8例再障。马利兰用量为每
Drug-induced hematological disease accounts for about 10% of all blood diseases, of which the highest incidence of leukopenia and agranulocytosis. First, aplastic anemia: drug-induced aplastic anemia (aplastic anemia) is divided into two categories, one is reversible myelosuppression, one is specific reaction. Reversible myelosuppression is due to drug inhibition of bone marrow mitochondrial protein synthesis, iron chelatase activity decreased, hemoglobin can not be synthesized, resulting in bone marrow erythroblasts, granulocytes and platelet disorders. Such drugs include alkylating agents and anti-metabolism drugs. Domestic reports with Maryland treatment of chronic myelogenous leukemia and psoriasis, induced aplastic anemia in 8 cases. Maryland amount for each