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应用乙酰胆碱选择性微电极技术，观察到小剂量赛拉嗪（２．０和６．０ｍｇ·ｋｇ－１）可显著增加大鼠海马ＣＡ１区ＡＣｈ的含量，而大剂量赛拉嗪（１０．０ｍｇ·ｋｇ－１）及咪唑克生（０．６ｍｇ·ｋｇ－１）则作用相反。咪唑克生虽可明显拮抗赛拉嗪的作用，但海马ＣＡ１区ＡＣｈ的含量仍显著低于正常水平。在去兰斑核的大鼠上，赛拉嗪（２．０和６．０ｍｇ·ｋｇ－１）及咪唑克生（０．６ｍｇ·ｋｇ－１）分别对海马ＣＡ１区ＡＣｈ的含量具有减少和增加作用，且咪唑克生拮抗赛拉嗪的作用后，海马ＣＡ１区ＡＣｈ的含量基本恢复至正常水平。结果提示，赛拉嗪对麻醉大鼠海马ＣＡ１区ＡＣｈ含量呈双相性影响，咪唑可生虽能显著拮抗赛拉嗪的作用，但海马ＣＡ１区ＡＣｈ的含量仍明显低于正常水平，可能分别与赛拉嗪和咪唑克生降低或提高中枢ＮＥ能系统的功能有关。
Using acetylcholine selective microelectrode technique, we observed that low dose xylazine (2.0 and 6.0 mg · kg -1) significantly increased ACh content in hippocampal CA1 region of rats, whereas high dose xylazine (10.0 mg Kg-1) and imidizumab (0.6 mg · kg-1). Although imidaclopide could obviously antagonize the effect of xylazine, the content of ACh in hippocampal CA1 area was still significantly lower than normal. In the rat with blue stained plaques, the levels of ACh in the hippocampal CA1 region were decreased and xylazine (2.0 and 6.0 mg · kg -1) and imidacloprid (0.6 mg · kg -1) After imidacloprid antagonized the action of xylazine, the content of ACh in hippocampal CA1 area returned to normal levels. The results suggest that xylazine anesthetized rat hippocampal CA1 ACh content showed a biphasic effect, although imidazole may significantly antagonize the role of xylazine, but the content of ACh in hippocampal CA1 area was still significantly lower than the normal level may be related to Xylazine and midazolam reduce or increase the central NE system function.