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目的 探讨化疗性闭经 (chemotherapy-induced amenorrhea, CIA) 发生、恢复情况及其影响因素.方法 通过对2013年1月～2014年12月期间哈尔滨医科大学附属第一医院甲状腺乳腺外科收治的166例乳腺癌患者进行随访, 统计记录患者治疗后术后化疗方案、周期、月经状况、内分泌治疗及其他辅助治疗信息.结果 其中≤35岁、35～40岁、40～45岁及≥45岁组CIA的发生率分别为35.7％、40.6％、70.6％和78.8％, 差异具有统计学意义 (P=0.0003) .服用他莫昔芬的患者发生CIA的概率为73.7％, 显著高于未服用他莫昔芬的患者 (P=0.0001) .结论 年龄和是否应用他莫昔芬是影响化疗性闭经发生的主要因素.“,”Objective To find out the predictors of chemotherapy-induced amenorrhea (CIA), and the factors which affect the happenning and recovery of CIA.Methods One hundred and sixty-six patients with breast cancer in The First Affiliated Hospital of Harbin Medical University from January 2013 to 2014 December were collected.The information on menstruation status, type and duration of chemotherapy, subsequent endocrine therapy and other treatments were collected.Results The CIA rate in patients aged ≤35 years old was 35.7％, and for patients aged in 35 ～ 40 years, 40 ～ 45 years and ≥45 years, the CIA rate were 40.6％, 70.6％and 78.8％, respectively.The difference was statistically significant (P = 0.0003).Patients using tamoxifen had a CIA rate of 73.7％, much higher than those who did not use.Conclusion Age and use of Tamoxifen are predictors of CIA.