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目的了解选择性剖宫产产妇围手术期抗生素使用时机与术后母儿感染的关系。方法将选择性剖宫产产妇1 019例,根据不同给药方案分为观察组501例,对照组518例。观察组断脐后5 min用抗生素一剂;对照组在切皮前30 min开始用抗生素,共用24~48 h。观察两组母儿感染率及抗生素用量。结果观察组和对照组在伤口感染、子宫内膜炎、尿路感染及新生儿黄疸与败血症发生率、入重症监护室率比较,差异无统计学意义(P>0.05)。结论剖宫产预防性应用抗生素的时机并不影响产后感染的发生率,单剂量抗生素能达到预期效果。
Objective To investigate the relationship between the timing of perioperative antibiotic use and maternal infection in postpartum women with selective cesarean section. Methods One hundred and ninety-nine women with selective caesarean section were divided into observation group (n = 501) and control group (n = 518) according to different dosage regimens. In the observation group, one dose of antibiotics was given 5 min after the umbilical cord was removed. In the control group, antibiotics were started 30 min before skin incision and shared 24-48 h. Two groups of mother-child infection rates and antibiotics were observed. Results The incidences of wound infection, endometritis, urinary tract infection, neonatal jaundice and sepsis in observation group and control group were not significantly different from those in intensive care unit (P> 0.05). Conclusion The timing of prophylactic use of antibiotics in cesarean section does not affect the incidence of postpartum infection, single-dose antibiotics can achieve the desired effect.