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目的研究金石清瘟解毒口服液对流感病毒B型与腺病毒(AdV3)的体外抑制作用。方法用微量细胞病变抑制法。按Reed-Muench法计算50%病变抑制的药物浓度(IC50),实验重复3次,并计算治疗指数(TI)。结果金石清瘟解毒口服液对流感病毒B型和腺病毒(AdV3)的IC50分别是(20.3±4.17),(40.03±8.56)mg/L。TI值分别是67和33.5;对照西药利巴韦林注射液对流感病毒B型和腺病毒(AdV3)的IC50分别是(48.6±10.11)mg/L和(50.61±11.72)mg/L。TI值分别是30和30。结论金石清瘟解毒口服液既可抗流感病毒B型,又可抗腺病毒(AdV3)。
Objective To study the inhibitory effect of Jingshi Qingwen Jiedu oral liquid on influenza virus B and adenovirus (AdV3) in vitro. Methods with micro-cytopathic effect inhibition method. The drug concentration (IC50) of 50% inhibition of the disease was calculated by Reed-Muench method. The experiment was repeated 3 times and the therapeutic index (TI) was calculated. Results The IC50 of Jinshi Qingwen Jiedu oral liquid against influenza virus B and adenovirus (AdV3) were (20.3 ± 4.17) and (40.03 ± 8.56) mg / L, respectively. TI values were 67 and 33.5, respectively. The IC50 values of ribavirin injection against influenza virus B and adenovirus (AdV3) were (48.6 ± 10.11) mg / L and (50.61 ± 11.72) mg / L, respectively. TI values are 30 and 30, respectively. Conclusion Jinshi Qingwen Jiedu oral liquid can both anti-influenza B and anti-adenovirus (AdV3).