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为了研究调理脾胃复方的抗痫作用，本实验采用放免法观察大鼠ＰＴＺ点燃以及服用调理脾胃复方治疗后，脑内阿片肽含量的变化。结果表明，ＰＴＺ点燃大鼠海马内亮脑啡肽（ＬＥＮＫ）、β内啡肽（βＥＰ）明显升高，强啡肽Ａ１－１３（ＤＹＮＡ１－１３）显著降低；大脑皮层内ＬＥＮＫ明显升高，ＤＹＮＡ１－１３、β－ＥＰ无明显变化。用调理脾胃复方治疗后，上述脑区ＬＥＮＫ、βＥＰ显著减少，ＤＹＮＡ１－１３明显增加。提示癫痫发作及调理脾胃复方抗痫作用可能与脑内ＬＥＮＫ、βＥＰ、ＤＹＮＡ１－１３的变化有关。
In order to study the anti-epilepsy effect of conditioned spleen-stomach compound, the change of brain opiate peptide content was observed by radioimmunoassay in rats with PTZ priming and after taking compound spleen-stomach compound treatment. The results showed that the levels of leu-enkephalin (L-ENK) and β-endorphin (β-EP) in the hippocampus of PTZ-ignited rats were significantly increased, and dynorphin A1-13 (DYNA1-13) was significantly decreased; L ENK increased significantly, DYNA1-13, β-EP did not change significantly. After conditioning spleen-stomach compound treatment, L-ENK and β-EP in the above-mentioned brain regions were significantly reduced, and DYNA1-13 was significantly increased. Tips on seizures and conditioning spleen and stomach compound anti-epilepsy may be related to changes in the brain L ENK, β EP, DYNA1-13.