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目的探讨依达拉奉治疗急性脑梗死的疗效及其对自由基含量的影响。方法选取68例急性脑梗死患者作为研究对象,根据治疗方法的不同分为观察组和对照组(n=34),对照组应用丹参酮I磺酸钠注射液,观察组应用依达拉奉注射液,比较2组患者的临床疗效及血清SOD(超氧化物歧化酶)、MDA(丙二醛)水平变化。结果观察组患者治疗后的MDA值为(8.10±1.03)μmol/L,显著低于对照组的(11.54±1.12)μmol/L(P<0.05);观察组治疗后的SOD水平为(97.77±13.56)IU/m L,显著高于对照组的(82.57±12.54)IU/m(L P<0.05);观察组患者的治疗总有效率为88.24%(30/34),显著高于对照组的64.71%(22/34)(P<0.05)。结论对急性脑梗死患者应用依达拉奉注射液,能有效降低自由基含量,改善患者神经功能,临床疗效显著,值得推广应用。
Objective To investigate the curative effect of edaravone on acute cerebral infarction and its effect on free radical content. Methods Sixty-eight patients with acute cerebral infarction were enrolled in this study. According to the different treatment methods, they were divided into observation group and control group (n = 34). In the control group, tanshinone I sodium sulfonate injection was used. In observation group, edaravone injection The clinical efficacy and serum SOD (superoxide dismutase), MDA (malondialdehyde) levels in two groups were compared. Results The MDA level in the observation group was (8.10 ± 1.03) μmol / L, significantly lower than that in the control group (11.54 ± 1.12 μmol / L, P <0.05). The SOD level in the observation group was 97.77 ± 13.56) IU / m L, which was significantly higher than that of the control group (82.57 ± 12.54 IU / m, LP <0.05). The total effective rate of the observation group was 88.24% (30/34), significantly higher than that of the control group 64.71% (22/34) (P <0.05). Conclusion The application of edaravone injection in patients with acute cerebral infarction can effectively reduce the content of free radicals and improve the neurological function of patients with significant clinical effect, which is worth popularizing and applying.