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目的 :研究大肠癌患者血清可溶性细胞表面分化抗原 s CD4 4v6 的表达水平及其临床意义。方法 :应用定量酶联免疫吸附 EL ISA法 ,检测 6 6例大肠癌患者血清 s CD4 4v6 的水平 ;同期应用免疫组化法 ,检测 s CD4 4v6 在其组织中的表达。结果 :大肠癌患者血清 s CD4 4v6 的水平明显高于正常人 ,s CD4 4v6 表达阳性的大肠癌患者血清 s CD4 4v6 的水平明显高于 s CD4 4v6 表达阴性的患者 ;s CD4 4v6 的水平与大肠癌的淋巴结转移及 Dukes 分期有关。结论 :血清 s CD4 4v6 可作为大肠癌辅助诊断及病情估计的一个重要的分子生物学指标。
Objective: To study the expression of s CD4 4v6 in patients with colorectal cancer and its clinical significance. Methods: Serum s CD4 4v6 level was detected in 66 cases of colorectal cancer patients by quantitative enzyme-linked immunosorbent assay (ELISA). The expression of s CD4 4v6 was detected by immunohistochemistry in the same period. Results: Serum s CD4 4v6 levels in patients with colorectal cancer were significantly higher than those in normal controls. Serum s CD4 4v6 levels were significantly higher in patients with colorectal carcinoma with CD4 + CD4 expression than in patients with s CD4 4v6 negative expression. The levels of s CD4 4v6 and colorectal Lymph node metastasis and Dukes staging. Conclusion: Serum s CD4 4v6 can be used as an important molecular biological indicator in the diagnosis and prognosis of colorectal cancer.