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胶质细胞在中枢神经损伤与修复中如同一把双刃剑:一方面促进轴突再生,产生一些神经营养因子支持轴突生长;另一方面又抑制轴突生长,局部胶质细胞形成坚硬的胶质瘢痕并分泌一些抑制性因子,阻碍轴突的生长、穿过等;然而少突胶质细胞的细胞膜及成熟中枢神经系统中广泛存在的髓鞘又是影响中枢神经系统再生的最重要因素之一。了解少突胶质细胞表达的抑制性蛋白抑制作用的机制对神经再生新途径的开辟具有重要意义。
Glial cells act as a double-edged sword in central nervous system injury and repair: on the one hand, they promote axon regeneration, produce some neurotrophic factors to support axonal growth; on the other hand, they inhibit the growth of axons and local glial cells form hard Glial scar and secretion of some inhibitory factor, hinder the growth of axons, through, etc .; however, the membrane of oligodendrocytes and mature myelin sheath in the central nervous system is the most important factor affecting the regeneration of the central nervous system one. Understanding the mechanism of inhibitory protein expression by oligodendrocytes is important for the development of new ways of neural regeneration.