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目的:探讨醒脑静联合血液灌流辅助治疗有机磷农药中毒的临床疗效。方法:将2010年3月至2012年6月我科诊治的急性中重度有机磷中毒患者59例随机分为观察组(n=32)和对照组(n=27),其中观察组采用醒脑静联合血液灌流,对照组仅用血液灌流,比较两组间的阿托品用量,昏迷至清醒时间,机械通气例数,胆碱酯酶(CHE)恢复正常时间,反跳现象例数,中间综合征例数。结果:观察组阿托品总用量,昏迷至清醒时间,机械通气例数,CHE恢复正常时间均明显低于对照组(P<0.05),两组反跳现象,中间综合征例数无统计学差异(P>0.05)。结论:醒脑静联合血液灌流治疗有机磷农药中毒较单纯血液灌流能明显减少阿托品用量,加快血CHE活性恢复,使昏迷至清醒时间缩短。
Objective: To investigate the clinical effect of Xingnaojing combined with hemoperfusion in the treatment of organophosphorus pesticide poisoning. Methods: From March 2010 to June 2012, 59 patients with acute moderate-severe organophosphorus poisoning who were diagnosed and treated in our department were randomly divided into observation group (n = 32) and control group (n = 27) The rats in the control group were treated with hemoperfusion only. The amount of atropine, coma to awake time, the number of mechanical ventilation, the recovery time of cholinesterase (CHE), the number of rebound phenomenon, the median syndrome Number of cases. Results: The total amount of atropine, the time from coma to awake, the number of mechanical ventilation and the recovery time of CHE in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference between the two groups in rebound phenomenon and the number of intermediate syndrome P> 0.05). Conclusion: Xingnaojing combined with hemoperfusion treatment of organophosphorus pesticide poisoning can significantly reduce the amount of atropine compared with pure hemoperfusion, accelerate the recovery of blood CHE activity and shorten the coma to awake time.