冠状动脉内溶栓疗法是急性心肌梗死后恢复冠状动脉血流灌注的方法之一,可减轻冠状动脉血栓负荷,缩小心肌梗死面积,保护濒死心肌,降低病死率。尽管随着介入方法的普及,冠状动脉内溶栓疗法的临床运用有所减少,但其在支架内血栓形成、特殊类型的冠状动脉病变、冠状动脉内血栓抽吸失败等方面仍有特殊应用。本文就冠状动脉内溶栓疗法应用的研究进展作一综述。 Intra-coronary thrombolysis is one of the methods to restore coronary blood flow after acute myocardial infarction, which can reduce the load of coronary artery thrombosis, reduce the area of ​​myocardial infarction, protect the dying myocardium and reduce the mortality rate. Although the clinical use of intra-coronary thrombolysis has decreased with the popularity of interventional methods, there are still specific applications in stent thrombosis, special types of coronary artery disease, and failure of coronary thrombus aspiration. This article reviews the research progress of the application of coronary thrombolysis.