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目的评价安定联合鲁米那交替静滴治疗破伤风的疗效。方法73例破伤风病例随机分为2组,对照组35例,采用5%GS 500m l+安定100mg持续静脉滴注;联合组38例,采用安定联合鲁米那交替静滴:5%GS 500m l+安定100mg及5%GS 500m l+鲁米那500mg,每4小时交替1次,两组皆根据病情调节药物滴速。结果联合组平均抽搐时间、平均住院时间比对照组短(P<0.01),气管切开率、死亡率亦比对照组低(P<0.05),未见明显毒副反应。结论安定联合鲁米那交替静滴治疗破伤风疗效优于单用安定持续静滴,是一种可取的治疗方案。
Objective To evaluate the efficacy of tranquilizer and luminal alternating infusion for tetanus. Methods A total of 73 cases of tetanus were randomly divided into two groups, 35 cases in the control group and 5% GS 500ml plus diazepam (100mg) for continuous intravenous infusion. In the combined group, 38 cases were treated with 5% GS 500ml + Stability 100mg and 5% GS 500m l Luminara 500mg, alternating every 4 hours 1, two groups are based on the condition to adjust the drug drip rate. Results The average twitch time and average length of hospital stay in the combined group were shorter than those in the control group (P <0.01). Tracheotomy and mortality rates were also lower than those in the control group (P <0.05). No obvious side effects were found. Conclusions The combination of amlodipine and luminal sodium in the treatment of tetanus by intravenous infusion is superior to the continuous intravenous infusion of diazepam, which is a desirable treatment.