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目的了解孕龄妇女和妊娠妇女TORCH(弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒)感染状况及其与不良妊娠之间的关系。方法应用酶联免疫吸附实验(ELISA)对266例孕龄妇女和725例妊娠妇女(包括69例不良妊娠及656例正常妊娠)进行TORCH-IgM抗体检测。结果孕龄妇女Toxo、RV、CMV、HSVI、HSVIIIgM的阳性率分别为3.7%、1.8%、6.0%、2.3%和4.1%,妊娠妇女的则分别为3.0%、2.2%、13.6%、3.2%和6.2%,妊娠妇女CMVIgM阳性率明显高于孕龄妇女(P<0.05);不良妊娠组与正常妊娠组之间的TORCH-IgM均有显著性差异,均以CMVIgM阳性率最高,其次为HSVIIIgM。结论本地区妊娠妇女CMV感染率高;TORCH系列病原体与不良妊娠密切相关,其中CMV、HS-VII在本地区对妊娠影响最大,二者均可经性接触传播。孕妇应常规、追踪进行TORCH血清学检测。
Objective To understand the status of TORCH (Toxoplasmosis, Rubella virus, Cytomegalovirus, Herpes simplex virus) infection in pregnant women and pregnant women and their relationship with adverse pregnancy. Methods TORCH-IgM antibodies were detected in 266 women of gestational age and 725 pregnant women (including 69 unwanted pregnancies and 656 normal pregnancies) by enzyme-linked immunosorbent assay (ELISA). Results The positive rates of Toxo, RV, CMV, HSVI and HSVIII gM were 3.7%, 1.8%, 6.0%, 2.3% and 4.1% in gestational age women and 3.0%, 2.2%, 13.6% and 3.2% in pregnant women respectively And 6.2% respectively. The positive rate of CMVIgM in pregnant women was significantly higher than that in pregnant women (P <0.05). TORCH-IgM was significantly different between adverse pregnancy group and normal pregnancy group, with the highest positive rate of CMVIgM, followed by HSVIIIgM . Conclusions CMV infection rate in pregnant women in this area is high. TORCH pathogens are closely related to adverse pregnancy. CMV and HS-VII have the greatest impact on pregnancy in the region, both of which can be transmitted by sexual contact. Pregnant women should routinely follow TORCH serological test.