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受试者为89名健康青年,分成3组.接种的疫苗为Merck药厂生产的重组乙型肝炎疫苗,每剂含10μgHBsAg.Ⅰ组于0、1、2和12个月接种;Ⅱ组于0、1和6个月接种;Ⅲ组于0、1和12个月接种.分别于1～7个月的每月及9、12、13个月和2年采血.用放射免疫法检测HBsAg、抗-HBs和抗-HBc.接种第3针后1个月,Ⅰ组产生的抗-HBs水平略高于其他两组接种两针后的水平.嗣后的1个月抗-HBs增长缓慢,7个月时达高峰,除1人外,抗-HBs滴度均>
The subjects were 89 healthy youths and were divided into three groups.The vaccine inoculated was a recombinant hepatitis B vaccine produced by Merck Pharmaceutical Factory with 10 μg HBsAg per dose.Ⅰgroup was inoculated at 0, 1, 2 and 12 months; group Ⅱ 0, 1 and 6 months after inoculation. Group Ⅲ was inoculated at 0, 1 and 12 months, respectively, at 1 month, 7 months, 9 months, 12 months and 2 years respectively. HBsAg was detected by radioimmunoassay , Anti-HBs and anti-HBc.The level of anti-HBs produced in group I was slightly higher than that of the other two groups one month after inoculation on the third needle.After one month, anti-HBs grew slowly, The peak reached at 7 months, with the exception of one, anti-HBs titer>