卡尔曼滤波分光光度法是按卡尔曼滤波理论的递推方程对相互重迭的多组份混合物的光谱曲线数据进行快速滤波,从而得出各组份的含量。文章介绍了该方法的基本原理和递推方程,给出了卡尔曼滤波的算法程序框图。以复方磺胺甲氧吡嗪片中磺胺甲氧吡嗪(SMPZ)和甲氧苄氨嘧啶(TMP)的测定为例,说明了实验方法。从220-350nm,间隔2nm共测59个 Kalman filter spectrophotometry is based on the Kalman filter theory of recursive equations of the overlapping multi-component mixture of spectral curve data for rapid filtering, to obtain the content of each component. The article introduces the basic principle of the method and recursive equations, and gives the algorithm block diagram of Kalman filter. Taking sulfamethoxazole (SMPZ) and trimethoprim (TMP) in compound sulfamethoxypyrazine tablets as an example, the experimental method is described. A total of 59 cells were tested from 220-350nm with 2nm intervals