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研究前列腺特异抗原在乳腺癌组织中的表达及其与ER、PR表达的关系。方法 :采用免疫组化法检测 10 2例乳腺癌的抗人体前列腺特异抗原 (PSA) ,雌激素受体 (ER)和孕激素受体 (PR)。结果 :2 6例PSA阳性(2 5 5 % ) ,PSA+ 和ER+ 、PR之间存在密切关系 (P <0 0 5 )。PSA+ 、ER+ 的乳腺癌液下淋巴结转移率明显低于PSA- 、ER- 的乳腺癌 (P <0 0 5 )。结论 :PSA、ER、PR表达具有较强的一致性 ,乳腺癌的PSA与肿瘤大小、生物学特性、ER状态及淋巴结转移有明显的相关性 ,PSA阳性表达乳癌预后较好
To study the expression of prostate specific antigen in breast cancer and its relationship with the expression of ER and PR. Methods: The anti-human prostate specific antigen (PSA), estrogen receptor (ER) and progesterone receptor (PR) were detected by immunohistochemistry in 102 cases of breast cancer. Results: Twenty-six cases were positive for PSA (25.5%), and there was a close relationship between PSA + and ER +, PR (P <0.05). The rates of subcutaneous lymph node metastasis in PSA + and ER + breast cancer were significantly lower than those in PSA- and ER- -dependent breast cancer (P <0.05). CONCLUSIONS: The expression of PSA, ER and PR have strong consistency. The PSA of breast cancer has significant correlation with tumor size, biological characteristics, ER status and lymph node metastasis. The positive expression of PSA in breast cancer is better