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目的 探讨血管生成抑制剂 细胞毒药物联用疗法 [TNP 4 70 / 2′ ,2′ 二氟脱氧胞苷 (Gemc itabine) ]对胰腺癌裸鼠原位移植模型 (SOI)生长、转移的抑制作用。方法 单用疗法 :2 4只胰腺癌SOI模型随机分为T3 0组 (TNP 4 70 3 0mg/kg ,皮下注射 ,隔日一次 ,疗程 8周 )、G10 0组 (Gemcitabine 10 0mg/kg ,腹腔内给药 ,术后第 0、3、6、9天 )和对照组 ;联用疗法 :3 2只SOI模型随机分为T15组、G5 0组、对照组和联用组 (采用T3 0 +G5 0 ) ,术后第 10周处死裸鼠。结果 G10 0侧重于抑制胰腺癌生长 ,T3 0则侧重抑制胰腺癌转移 ,两者均无显著的改善预后作用 ;T15和G5 0无显著的抗肿瘤生长和转移作用 ;只有联用组能显著抑制胰腺癌生长、转移和改善预后 ,T3 0可使G5 0的抑瘤率提高 2倍 ,并获得 2 / 8只的肿瘤治愈率 ;T3 0组的微血管密度为 7.13± 2 .99/高倍视野 ,显著低于T15组的 10 .5 3± 3 .2 2 /高倍视野和对照组的 14 .5 0± 5 .93 /高倍视野 (P <0 .0 5 )。结论 血管生成抑制剂 细胞毒药物联用疗法 (TNP 4 70 3 0mg/kg和Gemcitabine 5 0mg/kg)能有效抑制肿瘤生长和转移 ,有助于减少细胞毒药物剂量及不良反应 ,为安全有效的抗肿瘤策略。
Objective To investigate the inhibitory effect of angiogenesis inhibitor cytotoxic drug combination therapy (TNP 4 70 / 2′, 2′-difluorodeoxycytidine) on the growth and metastasis of pancreas cancer in orthotopic transplanted model (SOI) . Methods Single-use therapy: 24 SOI models of pancreatic cancer were randomly divided into T3 0 group (TNP 4 70 30 mg/kg, subcutaneously, every other day for 8 weeks), G10 0 group (Gemcitabine 100 mg/kg, intraperitoneally Dosing, 0, 3, 6 and 9 days after operation) and control group; combination therapy: 32 SOI models were randomly divided into T15 group, G50 group, control group and combination group (using T3 0 + G5 0) The nude mice were sacrificed at the 10th week after operation. Results G10 0 was focused on inhibiting the growth of pancreatic cancer. T30 was focused on inhibiting the metastasis of pancreatic cancer. Both of them had no significant effect on prognosis; T15 and G50 had no significant anti-tumor growth and metastasis effects; only the combined group significantly inhibited the growth. For pancreatic cancer growth, metastasis, and improved prognosis, T3 0 can increase the tumor inhibition rate of G50 by 2 times, and obtain a 2/8 tumor cure rate; the T3 0 group has a microvessel density of 7.13±2.99/high power field. Significantly lower than the 10.53±3.22/high power field in the T15 group and 14.5±5.39/high power field in the control group (P<0.05). Conclusion The combination of angiogenesis inhibitor cytotoxic drugs (TNP 4 70 30 mg/kg and Gemcitabine 50 mg/kg) can effectively inhibit tumor growth and metastasis and help reduce cytotoxic drug doses and adverse reactions. It is safe and effective. Anti-tumor strategy.