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目的:探讨口服伏立康唑治疗的侵袭性肺部真菌感染（IPFI）高龄患者短期预后状况及其影响因素。方法:检索首都医科大学附属北京友谊医院信息系统，收集2016年1月至2017年12月在老年科住院、临床诊断为IPFI并口服伏立康唑治疗的高龄（≥80周岁）患者的电子病历，记录患者基本信息、基础疾病、合并用药、肝肾功能水平基线值、口服伏立康唑疗程以及用药后30 d内肝肾功能和生存状况，采用多因素Logistic回归方法分析患者口服伏立康唑后30 d内发生全因肝损伤、急性肾损伤（AKI）和死亡的影响因素，计算比值比（n OR）及其95%置信区间（n CI）。n 结果:纳入分析的患者共34例，男性20例，女性14例；年龄（91±5）岁；口服伏立康唑后30 d内，发生肝损伤者6例（17.6%），发生AKI者7例（20.5%），死亡9例（26.5%）。多因素Logistic回归分析结果显示，年龄是口服伏立康唑后30 d内发生肝损伤的独立危险因素（n OR=1.33，95n %CI：1.03~1.73，n P=0.03），基线估算肾小球滤过率（eGFR）n <60 ml/（min·1.73 mn 2）是发生AKI的独立危险因素（n OR=13.00，95n %CI：1.27~133.29，n P=0.03），AKI是30 d内死亡的独立危险因素（n OR=48.00，95n %CI：4.21~547.18，n P<0.01）。n 结论:高龄IPFI患者口服伏立康唑后30 d内发生肝损伤、AKI和死亡的风险较高，年龄、基线eGFRn <60 ml/（min·1.73 mn 2）分别是发生肝损伤和AKI的独立危险因素，AKI是死亡的独立危险因素。n “,”Objective:To explore the short-term prognosis and influencing factors of oral voriconazole in elderly patients with invasive pulmonary fungal infection (IPFI).Methods:By searching hospital information system in Beijing Friendship Hospital, Capital Medical University, the medical records of elderly patients (≥80 years) who were diagnosed as IPFI and treated with oral voriconazole in Department of Geriatrics from January 2016 to December 2017 were collected and analyzed retrospectively. The basic information, basic diseases, combined medication, baseline value of liver and kidney function, treatment course of oral voriconazole, and liver and kidney function and survival status within 30 days after medication were recorded. The influencing factors of all-cause liver injury, acute renal injury (AKI), and death within 30 days after oral voriconazole were analyzed by multivariate logistic regression. The odds ratio (n OR) and its 95% confidence interval (n CI) were calculated.n Results:A total of 34 patients were entered, including 20 males and 14 females with age of (91±5) years. Of them, 6 patients (17.6%) developed liver injury, 7 patients (20.5%) developed AKI, and 9 patients (26.5%) died within 30 days after treatment with oral voriconazole. Multivariate logistic regression analysis showed that age was an independent risk factor for liver injury within 30 days after treatment with oral voriconazole (n OR=1.33, 95n %CI: 1.03n -1.73, n P=0.03), baseline estimated glomerular filtration rate (eGFR)n <60 ml/ (min·1.73 mn 2) was an independent risk factor for AKI (n OR=13.00, 95n %CI: 1.27n -133.29, n P=0.03), AKI was an independent risk factor for death within 30 days (n OR=48.00,95n %CI: 4.21n -547.18, n P<0.01).n Conclusions:The risk of liver injury, AKI, and death was higher within 30 days after oral administration of voriconazole in elderly patients with IPFI. Age and baseline eGFRn <60 ml/(min·1.73 mn 2) were independent risk factors for liver injury and AKI, respectively. AKI was an independent risk factor for death.n