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目的探讨Pim蛳2基因在成人急性白血病患者中的表达。方法应用半定量RT蛳PCR方法分别检测38例健康对照者和194例急性白血病患者Pim蛳2基因的表达。结果正常人Pim蛳2基因的表达最高,Pim蛳2/G3PDH的半定量比值分别为(1.188±0.471);急性淋巴细胞白血病初治及复发患者Pim蛳2基因的表达最低,分别为(0.682±0.590)与(0.800±0.538),与正常组差异有显著性(P<0.05),急性髓系白血病初治和复发患者与正常人Pim蛳2基因的表达无明显差异,其半定量比值为(0.903±0.590)及(0.861±0.544)。结论急性淋巴细胞白血病初治及复发患者Pim蛳2基因的表达低于正常人。
Objective To investigate the expression of Pim 蛳 2 gene in adult patients with acute leukemia. Methods Semi-quantitative RT PCR was used to detect the expression of Pim 蛳 2 in 38 healthy controls and 194 acute leukemia patients. Results The Pim 蛳 2 gene expression was the highest in normal subjects and the Pim 蛳 2 / G3PDH was (1.188 ± 0.471), Pim 蛳 2 was lowest in patients with newly diagnosed and relapsed acute lymphoblastic leukemia (0.682 ± 0.590) and (0.800 ± 0.538), respectively. There was no significant difference in the expression of Pim 蛳 2 gene between the newly diagnosed and recurrent acute myeloid leukemia patients and normal controls (P <0.05) 0.903 ± 0.590) and (0.861 ± 0.544). Conclusion The expression of Pim 蛳 2 gene in patients with newly diagnosed and relapsed acute lymphoblastic leukemia is lower than that in normal people.