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胰岛素样生长因子 -II(IGF-II)是一种重要的生殖调节因子。本文比较了人工流产与药物流产蜕膜中 IGF-II基因表达水平。结果显示人工流产蜕膜中 IGF-II基因呈现普遍的高表达 ,其基因转录相对值为 1 .5 4± 0 .79,而药物流产的蜕膜中 IGF-II基因表达显著下降 ,其基因转录相对值为 0 .72± 0 .39,两者有显著性差异 (P<0 .0 5 )。结论 :IGF-II可能介导了孕激素对蜕膜的支持作用 ,并且参与了药物流产的分子机制
Insulin-like growth factor-II (IGF-II) is an important reproductive regulator. This article compares the level of IGF-II gene expression in decidua with abortion and abortion. The results showed that IGF-II gene was highly expressed in decidua induced by abortion, the relative value of gene transcription was 1.54 ± 0.79, while IGF-II gene expression in decidua was significantly decreased, and the gene transcription The relative value was 0.72 ± 0.39, there was a significant difference between the two (P <0. 05). CONCLUSION: IGF-II may mediate progesterone support for decidua and is involved in the molecular mechanism of medical abortion