心源性恶病质患者生长激素、胰岛素、胰岛素样生长因子1信号的变化

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心源性恶病质是慢性充血性心力衰竭发展到后期的一个不可逆过程.它的特点是新陈代谢、炎症、内分泌途径的重构.胰岛素、生长激素和胰岛素样生长因子1(IGF-1)参与葡萄糖,蛋白质和脂类的新陈代谢过程,调节机体构成.心源性恶病质患者体内的上述三个信号受损,导致合成/分解代谢失衡.该文就近年来国内外对心源性恶病质患者生长激素、胰岛素、IGF-1信号的变化、发生机制及细胞因子对其调控的研究进行综述,以期为日后心源性恶病质的治疗提供理论依据.
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