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目的探讨血清胱抑素C(CysC)对糖尿病早期肾损害的诊断价值。方法分别检测53例2型糖尿病患者(研究对象)和20例健康人员(对照组:N组)的血清CysC、β2-MG、血清肌酐(Scr)、内生肌酐清除率(Ccr)等相关指标进行比较。结果 CysC、β2-MG、Ccr均与VAER有良好的相关性,CysC与相关指标的相关性最强。结论血CysC较血肌酐、内生肌酐清除率能更敏感、更准确的反映2型糖尿病早期肾损害,是肾脏早期损伤的重要标志。
Objective To investigate the diagnostic value of serum cystatin C (CysC) in early diabetic nephropathy. Methods Serum levels of CysC, β2-MG, Scr and Ccr were measured in 53 patients with type 2 diabetes mellitus (subjects) and 20 healthy people (control group: N) Compare. Results CysC, β2-MG and Ccr had good correlation with VAER, and CysC showed the strongest correlation with related indicators. Conclusion The serum CysC is more sensitive than serum creatinine and endogenous creatinine clearance rate and more accurately reflects the early renal damage of type 2 diabetes. It is an important marker of early kidney damage.