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本文对食管癌高发区辉县孟庄乡的15～26岁人群的慢性食管炎患病率及其危险因素作了调查。对接受内镜与粘膜活检检查的538例研究对象,作了已知或可疑危险因素调查与组织病理诊断。在多因素病例对照分析中,以轻度、中度食管炎和对照组(食管正常和极轻度炎症)比较。轻中度食管炎患病率与过热饮食,同胞(兄弟姐妹)及食管癌家属史呈正相关。而和新鲜水果与主粮小麦的用量呈负相关。在单项因素分析中,食管炎和口腔白斑及脂溢性皮炎有关,这可能与共同有害因素,如吸烟与营养缺乏有关。调查结果表明,人生早年在生活环境中接触危险因素与营养缺乏,是引起食管炎与食管上皮防护机能减弱的原因,并可能形成食管癌发生的易感条件。
This article investigated the prevalence and risk factors of chronic esophagitis in 15 to 26-year-old people in Mengzhuang Town, Huixian County, a high incidence area of esophageal cancer. A total of 538 subjects who underwent endoscopic and mucosal biopsy examinations were investigated for known or suspected risk factors and histopathological diagnosis. In a multivariate case-control analysis, comparisons were made between mild and moderate esophagitis and controls (normal and very mild esophageal inflammation). The prevalence of mild to moderate esophagitis was positively associated with overheated diets, history of siblings (siblings) and family members of esophageal cancers. However, it was negatively correlated with the amount of fresh fruit and staple wheat. In a single factor analysis, esophagitis was associated with oral leukoplakia and seborrheic dermatitis, which may be related to common harmful factors such as smoking and nutritional deficiencies. The results of the survey indicate that the risk factors and nutritional deficiencies in the early life cycle of exposure to the living environment are the causes of weakened esophageal and esophageal epithelial protective function, and may be the predisposing conditions for esophageal cancer.