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目的观察黄芪配合奥扎格雷注射液治疗早期糖尿病肾病的疗效。方法将70例患者随机分为2组,在原糖尿病治疗方案基础上,对照组予黄芪注射液30 mL加生理盐水250 mL静点,治疗组予黄芪注射液30 mL和奥扎格雷注射液80 mg分别加入生理盐水250 mL中静滴。均1次/d,疗程21 d。结果治疗组内生肌酐清除率、尿微量白蛋白、血栓素、血糖均明显下降,血浆前列环素增高,与对照组比较有显著性差异。治疗组总有效率明显高于对照组(P<0.05)。结论黄芪配合奥扎格雷注射液治疗早期糖尿病肾病疗效优于单用黄芪。
Objective To observe the curative effect of Astragalus combined with ozagrel injection on early diabetic nephropathy. Methods 70 patients were randomly divided into two groups. On the basis of the original diabetes mellitus treatment program, the control group was given Astragalus Injection 30 mL and normal saline 250 mL, the treatment group was given astragalus injection 30 mL and ozagrel 80 mg Add 250 mL of normal saline intravenously. 1 times / d, treatment of 21 d. Results The endogenous creatinine clearance rate, urinary microalbumin, thromboxane and blood glucose in the treatment group were significantly decreased, plasma prostacyclin increased, compared with the control group were significantly different. The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). Conclusion Astragalus with ozagrel injection treatment of early diabetic nephropathy better than single astragalus.