龋病是发生于牙体硬组织的慢性感染性疾病，是加重或诱发全身疾病的主要口腔疾病之一。近年来随着高通量多组学技术、疾病动物模型与临床队列研究的进步，以及新型口腔材料与数字化、微创技术的发展，龋病的病因学研究与临床诊疗等方面均取得了较快的发展，全生命周期龋病管理理念更将龋病纳入全身慢性病防治体系，为不同年龄段龋病的群体管理和不同风险因素的个体化防治指明了方向。应进一步加强龋病的基础与临床研究，加快龋病防治新技术、新材料和新器械的临床验证，为龋病的早期诊断、综合预防以及功能与美学并重的微创诊疗提供有力手段，推动我国龋病研究水平的整体提升。“,”Dental caries is a chronic infectious disease that occurs in the tooth hard tissues. Increasing evidence has also indicated a close involvement of dental caries in the onset and development of systemic diseases. In recent years along with the advances in high throughput-omics technologies, disease animal models, multicenter clinical studies, as well as the research and development in novel dental materials, digital and minimal invasive clinical techniques, robust progress have been made in the field of etiology, pathogenesis, diagnosis, prevention and treatment of dental caries. More importantly, the strategy of whole life cycle management of caries has promoted the combinatory management of dental caries and other systemic chronic diseases, and it has also shed light on the age-based management and risk-control-oriented personalized treatment of caries. In the future, more efforts should be warranted to further the basic research and accelerate its clinical application, so as to advance the early diagnosis, comprehensive prevention and functional-aesthetic treatment with minimal invasive intervention of carious teeth, and ultimately to promote the population-based whole lifecycle management of caries.