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目的 探讨可溶性白细胞介素 - 6受体 (SIL - 6R)及其 β链 (Sgp130 )在监测胎膜早破中的作用。方法 采用酶联免疫吸附法检测 32例胎膜早破孕妇血清SIL - 6R、Sgp130水平 ,并以正常足月妊娠孕妇 2 0例作对照组。结果 胎膜早破孕妇血清SIL - 6R、Sgp130水平较正常妊娠组高 ,差异显著 (P <0 .0 1) ,随着破膜时间的延长孕妇血清SIL - 6R、Sgp130水平有增加趋势 ,绒毛羊膜炎孕妇血清SIL - 6R、Sgp130水平明显高于非绒毛羊膜炎孕妇 (P <0 .0 1)。结论 测定孕妇血清SIL - 6R、Sgp130水平可作为胎膜早破和绒毛羊膜炎的一个预测指标
Objective To investigate the role of soluble interleukin - 6 receptor (SIL - 6R) and its β chain (Sgp130) in the monitoring of premature rupture of membranes. Methods Serum levels of SIL - 6R and Sgp130 in 32 pregnant women with premature rupture of membranes were detected by enzyme - linked immunosorbent assay (ELISA). 20 pregnant women with normal term pregnancy were used as control group. Results Serum levels of SIL - 6R and Sgp130 in pregnant women with premature rupture of membranes were significantly higher than those in normal pregnant women (P <0.01). Serum levels of SIL - 6R and Sgp130 in pregnant women with premature rupture of membranes were increased, The levels of serum SIL - 6R and Sgp130 in pregnant women with amniotic inflammation were significantly higher than those in non - flu pregnancy (P <0.01). Conclusion The determination of serum levels of SIL - 6R and Sgp130 in pregnant women can be used as a predictor of premature rupture of membranes and chorioamnionitis