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目的探讨自体外周血造血干细胞移植(APBSCT)对系统性红斑狼疮(SLE)患者生活质量的影响。方法对21例住院的SLE患者进行APBSCT治疗。动员方案为环磷酰胺(CTX)4 g/m2,粒细胞集落刺激因子(G-CSF)5μg/(kg.d),4~5天。预处理方案为CTX 50 mg/(kg.d),4天;抗胸腺球蛋白(ATG)15~25 mg/(kg.d),3天。预处理结束后回输采集到的CD34+造血干细胞。采用WHOQOL-BREF中文版,观察并评价移植前后患者的生活质量评分。结果21例患者造血干细胞均成功植入。移植相关的死亡率为0%。WHOQOL-BREF表的五个方面,包括生理、心理、社会关系、环境、总体感觉等在移植后均有明显改善(P<0.05或P<0.01)。结论APBSCT治疗SLE有良好的疗效,患者在移植后生活质量明显改善。
Objective To investigate the effect of autologous peripheral blood stem cell transplantation (APBSCT) on the quality of life in patients with systemic lupus erythematosus (SLE). Methods 21 hospitalized SLE patients were treated with APBSCT. Mobilization regimens were CTX 4 g / m2 and G-CSF 5 μg / (kg.d) for 4-5 days. The pretreatment protocol was CTX 50 mg / (kg.d) for 4 days and anti-thymoglobulin (ATG) 15-25 mg / (kg.d) for 3 days. After the pretreatment, the collected CD34 + hematopoietic stem cells were transfused. The WHOQOL-BREF Chinese version was used to observe and evaluate the quality of life of patients before and after transplantation. Results 21 cases of patients with hematopoietic stem cells were successfully implanted. Transplant-related mortality was 0%. The five aspects of the WHOQOL-BREF table, including physical, psychological, social relationships, environment, general feeling and so on, all showed significant improvement after transplantation (P <0.05 or P <0.01). Conclusion APBSCT has a good curative effect on SLE, and the quality of life of the patients after transplantation is obviously improved.