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目的本研究考察了河豚毒素对20种不同组织人源肿瘤细胞株的体外抑瘤活性,以考察其对肿瘤细胞株的增殖影响。方法以经典细胞毒类药物顺铂作阳性对照,采用MTS法测定河豚毒素对肿瘤细胞增殖抑制作用。结果河豚毒素对MCF-7和PC-3等细胞株的增殖有较弱的抑制作用。结论河豚毒素可影响肿瘤细胞的增殖过程,电压门控钠离子通道可能与肿瘤细胞增殖有关。
Objective To investigate the in vitro antitumor activity of tetrodotoxin against 20 kinds of human tumor cell lines with different tissues in order to investigate the effect of tetrodotoxin on the proliferation of tumor cell lines. Methods The classic cytotoxic drug cisplatin as a positive control, the use of MTS assay tetrodotoxin inhibition of tumor cell proliferation. Results Tetrodotoxin had a weak inhibitory effect on the proliferation of MCF-7 and PC-3 cell lines. Conclusion Tetrodotoxin can affect the proliferation of tumor cells. The voltage-gated sodium channels may be involved in the proliferation of tumor cells.