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OBJECTIVE: To determine whether a false- positive 1- hour glucose challenge test (GCT) is associated with perinatal complications. METHODS: We performed a retrospective cohort study of 1825 eligible pregnantwomen among a cohort of 1998 patients. Patients were screened for gestational diabetes mellitus (GDM) with the 1- hour 50- g GCT at 24- 28 gestational weeks. A false- positive GCT was defined as a result greater than or equal to 135 mg/dL followed by a normal 3- hour glucose tolerance test (GTT).We compared the negative GCT and false- positive GCT cohorts for a composite perinatal outcome variable that included fetal macrosomia, antenatal death, shoulder dystocia, chorioamnionitis, preeclampsia, intensive care nursery admission, and postpartum endometritis. Secondary outcomes included cesarean delivery and each component variable of the composite. Unadjusted, stratified, and multiple logistic regression analyses were used to investigate the association between a false- positive GCT and the development of perinatal complications. RESULTS:We identified 164 patients with a false- positiveGCT and 50 patientswith GDM. The falsepositive GCT cohort on average was older, of higher parity, had a higher body mass index, and more frequently had chronic hypertension, sickle cell trait, and elevatedmidtrimester human chorionic gonadotropin levels. The false- positive GCT cohort more frequently had adverse perinatal outcomes, including the composite perinatal outcome (odds ratio 5.96, 95% con- fidence interval 1.47, 24.16), macrosomia greater than 4500 g (OR 3.66, 95% CI 1.30, 10.32), antenatal death (OR 4.61, 95% CI 0.77, 27.48), shoulder dystocia (OR 2.85, 95% CI 1.25, 6.51), endometritis (OR 2.18, 95% CI 1.03, 4.63), and cesarean delivery (OR 1.76, 95% CI 0.99, 3.14). CONCLUSION: A false- positive GCT is an independent risk factor for adverse perinatal outcomes.
METHODS: We performed a retrospective cohort study of 1825 eligible pregnant women among a cohort of 1998 patients. Patients were screened for gestational diabetes mellitus (GDM) with the 1-hour 50- g GCT at 24- 28 gestational weeks. A false- positive GCT was defined as a result greater than or equal to 135 mg / dL followed by a normal 3- Hour glucose tolerance test (GTT ). We compared the negative GCT and false- positive GCT cohorts for a composite perinatal outcome variable that included fetal macrosomia, antenatal death, shoulder dystocia, chorioamnionitis, preeclampsia, intensive care nursery admission, and postpartum endometritis. Secondarys include cesarean delivery and each component variable of the composite. Unadjusted, stratified, and multiple logistic regression analyzes were used to investigate the association between a false- positive GCT and the development of perinatal complications. RESULTS: We identified 164 patients with a false-positive GCT and 50 patients with GDM. The false positive GCT cohort on average was older, of higher parity, had a higher body mass index, and more frequent had chronic hypertension, The false-positive GCT cohort more frequent had adverse perinatal outcomes, including the composite perinatal outcome (odds ratio 5.96, 95% con- centration 1.47, 24.16), macrosomia greater than 4500 g (OR 2.66, 95% CI 1.30, 10.32), antenatal death (OR 4.61, 95% CI 0.77, 27.48), shoulder dystocia (OR 2.85, 95% CI 1.25, 6.51) 4.63), and cesarean delivery (OR 1.76, 95% CI 0.99, 3.14). CONCLUSION: A false- positive GCT is an independent risk factor for adverse perinatal outcomes.