骨质疏松症是一种老年性常见病,与众多因素相关,而遗传是其中的重要因素。本文从遗传学角度简要综述了近几年来国内外对维生素D受体基因、胶原基因、雌激素受体基因、转移生长因子β基因、降钙素受体基因等基因多态性与骨质疏松之间关系的研究,为骨质疏松的早期诊断以及采取进一步治疗奠定基础。 Osteoporosis is a common disease of the elderly that is related to a number of factors, of which genetic predisposition is an important factor. In this paper, we briefly reviewed the genetic polymorphisms of vitamin D receptor gene, collagen gene, estrogen receptor gene, metastatic growth factor β gene, calcitonin receptor gene and osteoporosis in recent years The relationship between the research for the early diagnosis of osteoporosis and to lay the foundation for further treatment.