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测２０例尿毒症患者血浆纤维连接蛋白（Ｆｎ）含量，证实尿毒症患者血浆Ｆｎ降低，并与患者中性粒细胞（ＰＭＮ）吞噬功能低下有关联。体外实验证实Ｆｎ有促进ＰＭＮ吞噬功能作用，且与其浓度正相关。表明血浆Ｆｎ与机体免疫防御功能关系密切，其水平可反映患者细胞吞噬功能状态。测４９例各种病理类型肾小球肾炎患者肾组织内Ｆｎ，发现Ｆｎ在系膜增生型肾炎中增高；在局灶节段或球性硬化型中减少。提示肾内Ｆｎ改变可反映肾小球系膜病变或发展规律，对其监测可能对观察肾小球疾病进展尤其硬化过程具有重要意义。
The plasma Fn in 20 patients with uremia was measured to confirm the decrease of plasma Fn in patients with uremia and associated with the phagocytosis of neutrophils (PMN). In vitro experiments confirmed Fn PMX phagocytosis function, and its concentration is positively correlated. That the plasma Fn and immune defense function is closely related to the level of the phagocytosis of patients can reflect the functional status. 49 cases of various pathological types of glomerulonephritis in patients with renal Fn, Fn found in mesangial proliferative nephritis increased; in focal segmental or sclerosis decreased. Prompt renal Fn changes can reflect the glomerular mesangial lesions or the development of its monitoring may be observed glomerular disease progression, especially the hardening process is of great significance.