多发性骨髓瘤(MM)是一种恶性浆细胞病,其肿瘤细胞起源于骨髓中的浆细胞,其特征为骨髓浆细胞异常增生伴有单克隆免疫球蛋白或轻链(M蛋白)过度生成,极少数患者可以是不产生M蛋白的未分泌型MM。MM约有80%的患者在病程中出现明显贫血[1],因而需要输注红细胞。本文讨论的是1例多发性骨髓瘤患者经过非血缘外周造血干细胞移植导致的血型正反定不符需要输血的情况。1病例资料 Multiple myeloma (MM) is a type of malignant plasma cell disease whose tumor cells originate in plasma cells in the bone marrow and are characterized by abnormal proliferation of bone marrow plasma cells associated with monoclonal immunoglobulin or light chain (M protein) over-production , A very small number of patients may be non-secreted MM that does not produce M protein. Approximately 80% of patients with MM have significant anemia during their course of disease [1] and therefore require transfusions of red blood cells. This article discusses the case of one patient with multiple myeloma who has a non-blood-based peripheral hematopoietic stem cell transplant that is incompatible with blood type transfusions. 1 case information