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目的:探讨宫颈癌组织存活素(Survivin)与血管内皮生长因子(VEGF)的表达与宫颈癌临床特征的关系以及两者的相关性。方法:采用免疫组化SP法检测73例宫颈癌,25例宫颈上皮内瘤样病变(CIN)和20例慢性宫颈炎组织Sur-vivin和VEGF的表达水平。结果:宫颈癌组织Survivin和VEGF阳性表达率分别为75.3%和78.1%,慢性宫颈炎组分别为5.0%和10.0%,CIN组分别为48.0%和52.0%。从慢性宫颈炎组到宫颈癌组,Sur-vivin和VEGF表达率逐渐升高,P<0.05。Survivin和VEGF的表达与宫颈癌临床分期及淋巴结转移相关。Survivin表达与VEGF表达呈正相关,r=0.738,P<0.01。结论:Survivin和VEGF在宫颈癌组织中的表达情况在一定程度上反映宫颈癌的局部浸润活性和转移潜能,与宫颈癌的转移、分期及预后密切相关。并在宫颈癌的发生,发展中可能存在协同作用。
Objective: To investigate the relationship between the expression of survivin and vascular endothelial growth factor (VEGF) in cervical cancer and clinical features of cervical cancer and their relationship. Methods: The expressions of Survivin and VEGF in 73 cases of cervical cancer, 25 cases of cervical intraepithelial neoplasia (CIN) and 20 cases of chronic cervicitis were detected by immunohistochemical SP method. Results: The positive rates of Survivin and VEGF in cervical cancer tissues were 75.3% and 78.1% respectively, while in patients with chronic cervicitis 5.0% and 10.0%, respectively, and those in CIN group were 48.0% and 52.0% respectively. From chronic cervicitis group to cervical cancer group, the expression of Sur-vivin and VEGF increased gradually, P <0.05. The expression of Survivin and VEGF is correlated with clinical stage and lymph node metastasis of cervical cancer. Survivin expression was positively correlated with VEGF expression (r = 0.738, P <0.01). Conclusion: The expression of Survivin and VEGF in cervical carcinoma may reflect the local infiltration activity and metastatic potential of cervical carcinoma to a certain extent, which is closely related to the metastasis, staging and prognosis of cervical cancer. And cervical cancer may occur in the development of synergies.