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介绍重组人红细胞生成素(Epo)主要的生理功能是促进原始红细胞的增殖和维持其活力。Epo主要由肾皮质和随质外肾小管周围毛细血管内皮细胞,其次是肝细胞产生的,它是一种基因重组的糖蛋白激素。可广泛地用于各种癌症、肾衰、炎症、慢性病、出血、手术等因素所引起的贫血。剂量50~300U·kg-1,一周3次,静脉、皮下注射皆可。常见的不良反应有血压升高,静脉血栓形成。长期应用无毒性、无器官功能障碍、无过敏反应或抗体形成、与其它生长因子有协同作用。
Introduction The main physiological function of recombinant human erythropoietin (Epo) is to promote the proliferation and maintain the vitality of primitive erythrocytes. Epo is mainly produced by the renal cortex and capillary endothelial cells surrounding the extranodal tubules, followed by liver cells, a genetically modified glycoprotein hormone. Can be widely used in a variety of cancer, renal failure, inflammation, chronic diseases, bleeding, surgery and other factors caused by anemia. Dose 50 ~ 300U · kg-1, 3 times a week, intravenous, subcutaneous injection can be. Common adverse reactions are blood pressure, venous thrombosis. Long-term use of non-toxic, no organ dysfunction, no allergic reaction or antibody formation, and other growth factors have synergistic effects.