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梅毒血清学固定是指梅毒患者经正规驱梅治疗后，血清滴度维持在低滴度不再下降的现象。其临床具有较高的发生率，并且发生机制尚不明确。近年来，国内外学者对此现象进行了大量研究总结，目前认为可能与梅毒治疗不规范、药物选择不当、梅毒的病期、治疗时梅毒血清抗体的基线滴度以及机体的免疫状态相关。梅毒血清学固定是梅毒复发、胎儿宫内感染以及发生神经心血管梅毒的危险因素。该文就其研究背景、概念，特别是病因、治疗方面进行综述。“,”Syphilis serofast( SSF) is a medical phenomenon,i.e.the serum titer remains on a low level without further decline after treatment.It has a high clinical incidence while the pathogenesis is still not very clear.In recent years,scholars at home and abroad have conducted a number of studies on this phenomenon. It′s currently considered that it may be associated with unstandardized syphilis treatment , improper drug selection,syphilis stage,syphilis serum antibody titers baseline during treatment,and the immune status of the body.SSF is a threat of recurrence,intrauterine infection,cardiovascular syphilis and neurosyphilis.Here is to make a review of the background and concepts of SSF,especially the cause and its treatment.