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采用流式细胞检测和Ｗｅｓｔｅｒｎ印迹分析法证明，人参皂甙Ｒｇ＿１可明显促进ＩＬ－２受体α链的表达和抑制可溶性ＩＬ－２受体的释放。Ｆｕｒａ－２荧光检测发现，Ｒｇ＿１对大鼠脾淋巴细胞的静息钙离子浓度和ＣｏｎＡ诱导的升钙效应均无明显影响，但却使ｃＡＭＰ和ｃＧＭｐ水平升高。鉴于环核苷酸在机体免疫调节中所起的重要作用，故可推测Ｒｇ＿１调节老年大鼠免疫功能的分子机制与其选择性提高脾淋已细胞内环核苷酸水平有关。
Using flow cytometry and Western blot analysis, it was shown that ginsenoside Rg_1 can significantly promote the expression of IL-2 receptor α chain and inhibit the release of soluble IL-2 receptor. Fura-2 fluorescence detection showed that Rg_1 had no significant effect on the resting calcium concentration of rat spleen lymphocytes and ConA-induced calcium rise but increased cAMP and cGMp levels. In view of the important role of cyclic nucleotides in immune regulation, it can be speculated that the molecular mechanism of Rg_1 regulating immune function in aged rats is related to its selective elevation of cyclic nucleotide levels in spleen cells.