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[目的]分析多系统萎缩(MSA)的临床特征。[方法]回顾性分析58例临床诊断MSA患者的临床资料。[结果]男性36例,女性22例,发病年龄33～75(55.8±9.3)岁。30(51.7%)例以行走不稳、言语不清等小脑症状为首发症状,22(37.9%)例以自主神经功能障碍为首发症状。37(63.8%)例MSA患者出现3个以上系统同时受累。MSA患者中40(70%)例表现有小脑萎缩;MSA-P患者中4例表现为延髓、脑桥和小脑萎缩。[结论]MSA是一种累及神经系统多部位的变性疾病,男性多于女性,中老年起病,缓慢进展,首发症状以小脑症状最多,其次为自主神经功能障碍。多数患者出现3个以上系统同时受累。MRI表现多以小脑萎缩为主,MSA-P患者也可表现为延髓脑桥小脑萎缩,对MSA诊断有肯定意义。本病暂无特殊治疗,预后差,但有些药物可改善部分患者临床症状。
[Objective] To analyze the clinical features of multiple system atrophy (MSA). [Methods] The clinical data of 58 patients with clinically diagnosed MSA were retrospectively analyzed. [Results] There were 36 males and 22 females with the onset age of 33-75 (55.8 ± 9.3) years old. In 30 (51.7%) cases, cerebellar symptoms such as unstable walking and unclear speech were the first symptoms, and 22 (37.9%) cases were characterized by autonomic dysfunction as the first symptom. 37 (63.8%) cases of MSA patients appear more than three systems involved. Cerebral atrophy was observed in 40 (70%) of MSA patients; medulla oblongata, pontine and cerebellar atrophy in 4 of the MSA-P patients. [Conclusion] MSA is a degenerative disease involving multiple parts of the nervous system. There are more males than females, with onset and slow progress in middle-aged and elderly patients. MSA has the most cerebellar symptoms in the first symptom, followed by autonomic dysfunction. Most patients appear more than 3 systems involved at the same time. Most MRI manifestations of cerebellar atrophy, MSA-P patients can also be expressed as medulla oblongata cerebellar atrophy, the diagnosis of MSA has a positive meaning. No specific treatment of this disease, the prognosis is poor, but some drugs can improve some patients with clinical symptoms.