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目的探讨肠道病毒(enterovirus,EV)在北京地区儿童急性呼吸道感染(acute respiratory infection,ARI)中的关系及月份、年龄和性别分布特点。方法选择402例ARI患儿,取其鼻咽深部分泌物,用逆转录聚合酶链反应(RT-PCR)方法检测EV。对检测出EV阳性的患儿进行月份分布、年龄分布和性别分布的统计分析。结果402例标本中检出EV阳性共70例,阳性率为17.4%。下呼吸道感染EV阳性率为17.7%,上呼吸道感染EV阳性率为15.9%。EV在不同月份阳性率为0~36.1%,以2004年5月份阳性率最高(36.1%),2005年12月份阳性率较低(4.3%)。除12岁以上组患儿未检测到EV阳性外,在各年龄组患儿中的EV阳性率为14.8%~21.9%,4~6岁组阳性率最低,7个月至1岁组阳性率最高。EV感染的男性患儿占男性病例的16.2%,女性患儿占女性病例的19.7%。结论住院ARI患儿中,EV在下呼吸道感染中占有重要位置;春末至秋季EV阳性率较高,冬季较低;12岁以下的ARI患儿中各年龄段EV感染普遍存在;性别上无统计学意义。
Objective To investigate the relationship between enterovirus (EV) in children with acute respiratory infection (ARI) in Beijing and its distribution characteristics of month, age and gender. Methods A total of 402 children with ARI were selected and their nasopharyngeal secretions were collected. The EV was detected by reverse transcription-polymerase chain reaction (RT-PCR). The monthly distribution, age distribution and gender distribution of EV positive children were statistically analyzed. Results A total of 70 EV positive cases were detected in 402 cases, the positive rate was 17.4%. Lower respiratory tract infection EV positive rate was 17.7%, upper respiratory tract infection EV positive rate was 15.9%. The positive rate of EV in different months was 0-36.1%, with the highest positive rate (36.1%) in May 2004 and the lower positive rate (4.3%) in December 2005. The EV positive rate was 14.8% ~ 21.9% in children of all age groups except for children over 12 years old, the lowest was in 4 ~ 6 years old group, the positive rate was in 7 months to 1 years old group highest. EVs infected males accounted for 16.2% of males and females accounted for 19.7% of females. Conclusions EV in infants with ARI occupies an important position in the lower respiratory tract infection. The EV positive rate is higher in late spring to autumn and lower in winter. The EV infection in all ARI children under 12 years of age is ubiquitous, with no statistics on gender Significance of learning.