【摘 要】
：
AIM: To investigate the relationship between 579 G＞T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of e
【机 构】
：
Department of Genetics & Developmental Biology, School of Basic Medical Sciences,Southeast Universit
论文部分内容阅读
AIM: To investigate the relationship between 579 G＞T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese.METHODS: DNMT3B 579 G＞T genotypes were determined by PCR-RFLP in 194 EC patients and 210 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed EC.RESULTS: In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 81.4%, 18.1%,90.05% and 9.55%, respectively. The distribution of genotypes and allelotypes in the EC patients was not significantly different from that in the controls.When stratified by sex and age, there was still no significant association between the risks of EC and GT and GG genotypes. This study also showed a distinct difference in the distribution of DNMT3B and single nucleotide polymorphism (SNP) between Chinese and Koreans.CONCLUSION: DNMT3B 579 G＞T polymorphism may not be a stratification marker to predict the susceptibility to EC, at least in Chinese. DNMT3B promoter SNP is diverse in ethnic populations.
其他文献
是Springer出版社继和后出版的转化医学丛书中的第三卷,主要探讨了基础研究在临床应用中的重要问题.本书涵盖了心血管医学中的最新进展,探寻有效的心血管转化医学研究,使之更
目的 分析躁狂期精神分裂症患者应用M ECT治疗的临床疗效及不良反应.方法 随机选取2017年1月-至2018年12月我院收治的106例躁狂期精神分裂症患者进行分组治疗研究,按照数字表
目的 观察缺血性脑血管病患者脑血管造影显示的血管狭窄或闭塞的比率及分布;探讨缺血性脑血管病与侧支循环代偿的关系,为动脉狭窄的诊断和干预提供依据.方法 回顾性分析138例
[目的]观察双(α-呋喃甲酸)氧钒(VO-FA)与六味地黄丸联合应用对糖尿病大鼠血糖血脂影响.[方法]用四氧嘧啶诱发糖尿病大鼠模型,分别以高、低剂量VO-FA联合六味地黄丸治疗,并设
对于糖尿病患者来说,食疗对于控制血糖和预防并发症效果明显.以下介绍10种糖尿病的饮食“克星”.rn1.柑橘类水果糖尿病患者体内维生素C的含量较低.虽然吃维C片补充得更快,但
AIM: To investigate the mechanism of action of thermal cutaneous stimulation on the gastric motor inhibition.METHODS: The gastric tone of 33 healthy volunteers
目的 观察新生鼠窒息后心肌组织缺血损伤情况以及心肌细胞线粒体膜通透性转换孔(mitochondrial permeability transition pore,MPTP)开放度的变化,以期揭示MPTP开放在窒息后心肌缺氧缺血及再灌注损伤的作用机制.方法 成年SD母鼠妊娠第21天行剖宫产,随机分为正常分娩组及动脉夹闭组,正常分娩组不夹闭子宫动脉,所分娩新生鼠为对照组；以夹闭动脉夹闭组孕鼠子宫动脉方
目的 讨论社区糖尿病护理综合干预效果分析.方法 选取110例我院在2016年3月到2018年3月治疗的糖尿病患者,根据患者的入院时间顺序分为实验组(社区糖尿病护理综合干预)和对照
The upper airway narrowing and changes in head posture and their relationship with apnea severity in patients with obstructive sleep apnea (OSA) were investigat
人们都听说,吃鱼对心脏有好处,因为鱼的脂肪和肉的脂肪大不一样,其中富含omega-3脂肪酸,特别是EPA,对降低血管炎症反应、降低血胆固醇、减少动脉硬化危险具有很好的作用.