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目的检测卵巢癌患者血清中人附睾分泌蛋白(HE)4、糖类抗原(CA)125和B7同源体(B7-H)4的表达,分析其意义。方法 68例卵巢癌患者术前血清标本为观察组,30例卵巢交界性肿瘤患者术前血清标本为对照组,体检未见明显器质性疾病的女性30例血清标本为正常对照组。留取清晨空腹血分离血清后进行HE4、CA125和B7-H4表达的检测。结果三组HE4、CA125和B7-H4的表达差异有统计学意义。观察组HE4、CA125和B7-H4表达与肿瘤淋巴结转移、临床分期密切相关,而三者表达与肿瘤病理类型无明显相关性。观察组HE4、CA125和B7-H4表达无明显相关性。结论卵巢癌患者血清中HE4、CA125和B7-H4高表达,三者对术前初筛肿瘤性质及判断病变程度可能有一定价值。
Objective To detect the expression of human epididymal secreted protein (HE) 4, carbohydrate antigen (CA) 125 and B7-H 4 in serum of patients with ovarian cancer and analyze its significance. Methods Seventy-eight serum samples of ovarian cancer patients as observation group, 30 patients with borderline ovarian tumor as control group and 30 healthy women without physical examination were selected as normal control group. After fasting serum samples were collected for early detection of HE4, CA125 and B7-H4 expression. Results The expression of HE4, CA125 and B7-H4 in three groups had statistically significant difference. The expression of HE4, CA125 and B7-H4 in the observation group was closely related to the metastasis and clinical stage of the tumor, but the expression of the three was not correlated with the pathological type of the tumor. The observation group HE4, CA125 and B7-H4 expression was not significantly correlated. Conclusions The serum levels of HE4, CA125 and B7-H4 in ovarian cancer patients are highly expressed, which may have some value on the nature of preoperative tumor screening and the degree of pathological changes.