白血病抑制因子(LIF)是IL-6家族中的一个多效性细胞因子,主要通过与其受体(LIF-R)结合后发挥作用,目前认为LIF是调节胚胎着床的关键因子之一,主要表现在大多数动物的子宫内膜在着床期LIF mRNA表达升高;子宫内膜中LIF基因表达缺失或减少将导致不孕,内膜中LIF的分泌在不同种类的动物受不同性激素的调控且其调节作用不一,着床前的胚胎以及一些细胞因子也可以促进子宫内膜中LIF mRNA的表达 Leukemia inhibitory factor (LIF) is a pleiotropic cytokine in the IL-6 family and plays a role mainly through binding to its receptor (LIF-R). LIF is currently considered as one of the key factors in regulating embryo implantation, mainly Manifested in most animals endometrium LIF mRNA expression increased during implantation; LIF endometrial loss or loss of LIF gene expression will lead to infertility, endometrial LIF secretion in different types of animals regulated by different sex hormones And its role in the regulation of different, pre-implantation embryo and some cytokines can also promote endometrial LIF mRNA expression