目的:观察四联递进治疗复发性细菌性阴道病疗效。方法:将张掖医学高等专科学校附属医院诊断为复发性细菌性阴道病的患者(排除妊娠和哺乳期患者)383例,随机分为两组。试验组进行四联递进联合治疗,对照组常规药物治疗,观察两组疗效、疗程,阴道菌群调整、副作用、复发率情况。结果:治疗组有效率为98.20%,对照组为82.87%。治疗组平均治疗时间为5.7天,对照组平均16.8天,治疗组疗程明显短于对照组。治疗组使用乳酸菌素片,明显提高了阴道乳酸菌量,改善了阴道内环境。经过1~3年随访,治疗组复发率7.18%,对照组复发率65.74%,治疗组复发率明显低于对照组。结论:四联递进疗法治疗复发性细菌性阴道病疗效好,疗程短、治疗器械简单、复发率低,可维持菌群平衡。 Objective: To observe the curative effect of recurrent bacterial vaginosis treated by quadruple instillation. Methods: 383 patients diagnosed as recurrent bacterial vaginosis at the Affiliated Hospital of Zhangye Medical College (excluding pregnancy and lactation patients) were randomly divided into two groups. The experimental group was treated with quadruplicate progressive combination therapy, and the control group was treated with conventional drugs. The curative effect, course of treatment, vaginal flora adjustment, side effects and recurrence rate were observed. Results: The effective rate was 98.20% in the treatment group and 82.87% in the control group. The mean treatment time was 5.7 days in the treatment group and 16.8 days in the control group. The course of treatment in the treatment group was shorter than that in the control group. Treatment group using lactobacillus tablets, significantly increased vaginal lactic acid bacteria, improve the vaginal environment. After 1 to 3 years follow-up, the recurrence rate was 7.18% in the treatment group and 65.74% in the control group, and the recurrence rate in the treatment group was significantly lower than that in the control group. Conclusion: The quadruple progressive therapy for recurrent bacterial vaginosis has good curative effect, short course of treatment, simple treatment device and low recurrence rate, which can maintain the flora balance.