TNF相关的凋亡诱导配体（TNF-related　apoptosis　inducing　ligand,TRAIL）为TNF超家族成员之一,能够与死亡受体结合,激活Caspase级联反应,选择性地诱导多种肿瘤细胞的凋亡,正常组织则对其不敏感,其调节机制与多种因素有关。TRAIL及其受体在脑胶质瘤表达与否存有异议,胶质瘤级胞系对TRAIL诱导凋亡敏感程度因其种类而不同,在体研究证明TRAIL对体内胶质瘤有显著的杀瘤效果,而没有其系统应用的肝脏毒性及局部应用的周围正常组织毒性。 TNF-related apoptosis inducing ligand (TNF-related apoptosis inducing ligand, TRAIL) is a member of the TNF superfamily, which binds to death receptors and activates Caspase cascade to selectively induce apoptosis of various tumor cells , Normal tissue is not sensitive to its regulation mechanism and many kinds of factors. TRAIL and its receptor expression in glioma or not, there is disagreement, glioma-grade TRAIL apoptosis induced by different types of sensitive, in vivo studies have shown that TRAIL significantly inhibited in vivo glioma Tumor effect without the hepatic toxicity of its systemic application and the local normal tissue toxicity of topical application.