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目的探讨第三产程口服米索前列醇与肌注催产素预防产后出血的疗效比较。方法将304例自然分娩产妇随机分为两组,将第三产程第一组口服400ug米索前列醇片,第二组肌肉注射10IU催产素,第三组未予以特殊处理。观察三组产妇产后出血发生率,监测分娩前后血红蛋白浓度和药物不良反应发生率。结果289人资料齐全,三组产后出血发生率分别为8.2%、6.7%和15.4%。米索组与催产素组出血发生率和分娩前后血红蛋白浓度变化无明显差异,但均与对照组的指标有显著性差异(p<0.05)。米索组不良反应率略高于催产素组的发生。两者不良反应少且轻微。米索前列醇片用药方便。费用低,起效快,在预防产后出血方面有很广阔的应用前景。
Objective To investigate the effect of oral administration of misoprostol and intramuscular oxytocin on the prevention of postpartum hemorrhage in the third stage of labor. Methods 304 cases of spontaneous delivery of women were randomly divided into two groups, the first stage of the third stage of oral administration of 400g misoprostol tablets, the second group intramuscular injection of 10IU oxytocin, the third group without special treatment. Observe the incidence of postpartum hemorrhage in the three groups and monitor the hemoglobin concentration and adverse drug reaction before and after childbirth. Results 289 complete data, the incidence of postpartum hemorrhage in the three groups were 8.2%, 6.7% and 15.4%. There were no significant differences in the incidence of hemorrhage between the misoprostol and oxytocin groups and before and after delivery, but both were significantly different from those of the control group (p <0.05). Misoprostol adverse reaction rate slightly higher than oxytocin group. Both adverse reactions and minor. Misoprostol tablets convenient medication. Low cost, rapid onset, in the prevention of postpartum hemorrhage has a very broad application prospects.