在急性脑损伤后检测体液中某些生化指标的改变,能从临床生化的角度上反映脑损伤的严重程度。髓鞘碱蛋白(Myelin BasicProtein,MBP)特异地位于中枢髓鞘少突胶质细胞膜上,约占髓鞘蛋白的30％。脑组织损伤能导致MBP向脑脊液中释放,如同时伴有血脑屏障的破坏,MBP释放进入血液中,检测MBP能较其他指标如乳酸脱氢酶、磷酸肌酸激酶等更具特异性。我们检测急性脑血管病患者血清MBP,结合临床表现和预后进行分析,探讨其临床意义。 The detection of certain biochemical changes in body fluids after acute brain injury can reflect the severity of brain injury from a clinical biochemical point of view. Myelin Basic Protein (MBP) is located specifically on the central myelin oligodendrocyte membrane, accounting for about 30% of myelin protein. Brain tissue injury can lead to the release of MBP to the cerebrospinal fluid, such as accompanied by the destruction of the blood-brain barrier, MBP release into the blood, MBP can be detected more than other indicators such as lactate dehydrogenase, creatine phosphokinase more specific. We detected serum MBP in patients with acute cerebrovascular disease, combined with clinical manifestations and prognosis analysis to explore its clinical significance.