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目的:观察苯磺酸左旋氨氯地平联合马来酸依那普利治疗中度原发性高血压的疗效及不良反应,探讨抗高血压药物联合应用的可行性。方法:将120例高血压患者随机分为观察组及对照A组、对照B组各40例。对照A组给予苯磺酸左旋氨氯地平片5mg,1次/d,口服;对照B组给予马来酸依那普利片10 mg,1次/d,口服;观察组给予苯磺酸左旋氨氯地平片5 mg联合马来酸依那普利片10 mg,1次/d,口服。3组疗程均为4周,观察治疗前、后患者血压、心率的变化,比较3组不良反应发生率。结果:观察组降压总有效率97.5%,高于对照A组(82.5%)和对照B组(67.5%),差异有统计学意义(P<0.05,P<0.01);对照A组心率较治疗前明显加快(P<0.05),对照B组及观察组心率与治疗前比较差异无统计学意义(P>0.05)。观察组不良反应发生率2.5%,低于对照A组(12.5%)和对照B组(7.5%),差异有统计学意义(P<0.05)。结论:苯磺酸左旋氨氯地平联合马来酸依那普利治疗中度原发性高血压疗效满意。
Objective: To observe the efficacy and side effects of levamlodipine besylate combined with enalapril maleate in the treatment of moderate essential hypertension and to explore the feasibility of the combination of antihypertensive drugs. Methods: 120 cases of hypertension were randomly divided into observation group and control group A, control group B 40 cases. The control group A was given levamlodipine besylate tablets 5mg once a day, while the control group B was given enalapril maleate 10mg once a day orally. The observation group was given levamisole benzelate Amlodipine tablets 5 mg enalapril maleate tablets 10 mg, 1 time / d, orally. The three groups were treated for 4 weeks, and the changes of blood pressure and heart rate were observed before and after treatment. The incidence of adverse reactions in the three groups were compared. Results: The total effective rate of hypotension in the observation group was 97.5%, higher than that in the control group A (82.5%) and the control group B (67.5%), the difference was statistically significant (P <0.05, P <0.01) There was no significant difference in heart rate between the control group B and the observation group before treatment (P <0.05). The incidence of adverse reactions in the observation group was 2.5%, which was lower than that in the control group A (12.5%) and the control group B (7.5%) (P <0.05). Conclusion: L-amlodipine besylate combined with enalapril maleate is effective in treating moderate essential hypertension.